Total Synthesis of the Alleged Structure of Crenarchaeol Enables Structure Revision**
نویسندگان
چکیده
Crenarchaeol is a glycerol dialkyl tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane-spanning undoubtedly structurally most sophisticated all known archaeal lipids and an iconic molecule organic geochemistry. The 66-membered macrocycle possesses unique chemical structure featuring 22 mostly remote stereocenters, cyclohexane ring connected by single bond to cyclopentane ring. Herein we report first total synthesis proposed crenarchaeol. Comparison with natural crenarchaeol allowed us propose revised crenarchaeol, wherein one stereocenters inverted.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202105384